Flexible Teaching at Boise State: A Guide for Faculty

Dynamic teaching requires creative and flexible thinking about how instructors can support students in achieving essential core course learning objectives. This guide offers suggestions for instructors at Boise State looking to continue offering a student-centered learning experience through a variety of teaching formats including, online, hybrid, and remote environments. While the process may feel unfamiliar and at times frustrating, try as much as possible to be patient. In times of disruption or change, everyone expects some pedagogical and technological hiccups. Be willing to switch tactics if something isn’t working. Focus on maintaining a growth mindset for both yourself and your students. Under normal circumstances, we make a point of conveying to our students how much we believe they can grow as learners in our courses and disciplines. Similarly, approach new teaching formats knowing that you and your students can and will succeed in this unfamiliar learning environment. Remember, while you might not be able to teach something exactly the way you imagined, as long as you’re still meeting the learning goals of the course, you’re doing fine

I nevertheless am a historian : Digital Historical Practice and Malpractice Around Black Confederate Soldiers

I have a good deal of interest in how members of the public who are not academically trained historians do history. For me, then, public history does not mean just projects, programs, and exhibits created by professional historians for the public, but rather the very broad and complex intersection of the public with historical practice. Provision those occupying this intersection with freely available digital tools and platforms, and things become interesting quickly. Because setting up a blog, wiki, or discussion forum means only a few mouse clicks, and archival resources are increasingly digitized, we are seeing a burgeoning of sites that coalesce communities around historical topics of interest. Even those who have no interest in setting up their own websites can participate in history-specific Facebook groups, blogging communities, and genealogy sites. Such digital spaces expand and blur considerably the spectrum of what counts as historical practice. For example, on Ancestry.com, users piece together family histories by synthesizing government records and crowdsourced resources of varying origin and credibility. Professional historians might take an active interest, then, in how digital archival and communication resources affect the spread or containment of particular historical myths.1 It is not clear, however, how these technologies aid academic historians in participating, or impede them from intervening, in these discussions. This chapter uses discourses about black Confederate soldiers to explore how digital technologies are changing who researches and writes history—as well as what authorial roles scholars are playing in the fuzzy edges of historical practice where crowdsourcing and the lay public are creating new research resources and narratives. These digital tools and resources not only are democratizing historical practice, but also providing professional historians with new opportunities and modes for expanding historical literacy

Pearl Kendrick, Grace Eldering, and the Pertussis Vaccine

State health department laboratories are crucial to the development of public health research

Translating the Knowledge Gap Between Researchers and Communication Designers for Improved mHealth Research

Our industry insight focuses on the challenges for health researchers collaborating with communication designers during the development of an App for improving maternal mental health and parenting stress. We discuss the challenges around explicating and communicating tacit and domain knowledge across disciplinary boundaries. We believe this report can widen communication design’s traditional focus on users in mHealth research to consider partnerships with academic researchers. The lessons learned from our experience developing a mHealth program can be used to reduce challenges in future mHealth research, especially for collaborations between health researchers and communications designers. Considering the growth of interest in mHealth, this is extremely relevant for future team satisfaction, the optimal use of research funds and industry time, and faster development of effective mHealth tools.This is the accepted manuscript version of the following publication: Rioux, C., Weedon, S., MacKinnon, A. L., Watts, D., Salisbury, M. R., Penner-Goeke, L., Simpson, K. M., Harrington, J., Tomfohr-Madsen, L. M. & Roos, L. E. (2022). Translating the Knowledge Gap Between Researchers and Communication Designers for Improved mHealth Research. SIGDOC '22: The 40th ACM International Conference on Design of Communication, USA, 157–160. doi: 10.1145/3513130.3558997BEAM was funded by a Research Manitoba COVID-19 Rapid Response Operating Grant. CR was supported by a Postdoctoral fellowship from Research Manitoba and the Children’s Hospital Foundation of Manitoba. ALM was supported by a Social Sciences & Humanities Research Council (SSHRC) Banting Postdoctoral Fellowship (#01353-000).Ye

Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells

Although it is well known that RET gene is strongly activated by retinoic acid (RA) in neuroblastoma cells, the mechanisms underlying such activation are still poorly understood. Here we show that a complex series of molecular events, that include modifications of both chromatin and DNA methylation state, accompany RA-mediated RET activation. Our results indicate that the primary epigenetic determinants of RA-induced RET activation differ between enhancer and promoter regions. At promoter region, the main mark of RET activation was the increase of H3K4me3 levels while no significant changes of the methylation state of H3K27 and H3K9 were observed. At RET enhancer region a bipartite chromatin domain was detected in unstimulated cells and a prompt demethylation of H3K27me3 marked RET gene activation upon RA exposure. Moreover, ChIP experiments demonstrated that EZH2 and MeCP2 repressor complexes were associated to the heavily methylated enhancer region in the absence of RA while both complexes were displaced during RA stimulation. Finally, our data show that a demethylation of a specific CpG site at the enhancer region could favor the displacement of MeCP2 from the heavily methylated RET enhancer region providing a novel potential mechanism for transcriptional regulation of methylated RA-regulated loci

Clinical information modeling processes for semantic interoperability of electronic health records: systematic review and inductive analysis

This is a pre-copyedited, author-produced PDF of an article accepted for publication in Journal of the American Medical Informatics Association following peer review. The version of record is available online at: http://dx.doi.org/10.1093/jamia/ocv008[EN] [Objective] This systematic review aims to identify and compare the existing processes and methodologies that have been published in the literature for defining clinical information models (CIMs) that support the semantic interoperability of electronic health record (EHR) systems. [Material and Methods] Following the preferred reporting items for systematic reviews and meta-analyses systematic review methodology, the authors reviewed published papers between 2000 and 2013 that covered that semantic interoperability of EHRs, found by searching the PubMed, IEEE Xplore, and ScienceDirect databases. Additionally, after selection of a final group of articles, an inductive content analysis was done to summarize the steps and methodologies followed in order to build CIMs described in those articles. [Results] Three hundred and seventy-eight articles were screened and thirty six were selected for full review. The articles selected for full review were analyzed to extract relevant information for the analysis and characterized according to the steps the authors had followed for clinical information modeling. [Discussion] Most of the reviewed papers lack a detailed description of the modeling methodologies used to create CIMs. A representative example is the lack of description related to the definition of terminology bindings and the publication of the generated models. However, this systematic review confirms that most clinical information modeling activities follow very similar steps for the definition of CIMs. Having a robust and shared methodology could improve their correctness, reliability, and quality. [Conclusion] Independently of implementation technologies and standards, it is possible to find common patterns in methods for developing CIMs, suggesting the viability of defining a unified good practice methodology to be used by any clinical information modeler.This research has been partially funded by the Instituto de Salud Carlos III (Platform for Innovation in Medical Technologies and Health), grant PT13/0006/0036 and the Spanish Ministry of Economy and Competitiveness, grants TIN2010-21388-C02-01 and PTQ-12-05620.Moreno-Conde, A.; Moner Cano, D.; Da Cruz, WD.; Santos, MR.; Maldonado Segura, JA.; Robles Viejo, M.; Kalra, D. (2015). Clinical information modeling processes for semantic interoperability of electronic health records: systematic review and inductive analysis. Journal of the American Medical Informatics Association. 22(4):925-934. https://doi.org/10.1093/jamia/ocv008S925934224Goossen W Goossen-Baremans A van der Zel M . Detailed clinical models: a review. Healthc Inform Res. 2010;16:201.Beeler, G. W. (1998). HL7 Version 3—An object-oriented methodology for collaborative standards development1Presented at the International Medical Informatics Association Working Group 16 Conference on Standardisation in Medical Informatics—Towards International Consensus and Cooperation, Bermuda, 12 September, 1997.1. International Journal of Medical Informatics, 48(1-3), 151-161. doi:10.1016/s1386-5056(97)00121-4Dolin, R. H., Alschuler, L., Boyer, S., Beebe, C., Behlen, F. M., Biron, P. V., & Shabo (Shvo), A. (2006). HL7 Clinical Document Architecture, Release 2. 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The Unified Software Development Process. Massachusetts, USA: Addison-Wesley Reading; 1999.Ahn, S., Huff, S. M., Kim, Y., & Kalra, D. (2013). Quality metrics for detailed clinical models. International Journal of Medical Informatics, 82(5), 408-417. doi:10.1016/j.ijmedinf.2012.09.006Kalra D . Editorial principles for the development of standards for the structure and content of health records. 2012. https://www.rcplondon.ac.uk/sites/default/files/documents/editorial-principles-for-the-development-of-record-standards.pdf. Accessed July 16, 2014.Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ, 339(jul21 1), b2535-b2535. doi:10.1136/bmj.b2535Transparent reporting of systematic reviews and meta-analyses (PRISMA). http://www.prisma-statement.org/. Accessed July 18, 2014.US National Library of Medicine. http://www.pubmed.gov. Accessed July 18, 2014.IEEE Xplore Digital Library. http://ieeexplore.ieee.org/. Accessed July 18, 2014.ScienceDirect. http://www.sciencedirect.com/. Accessed July 18, 2014.Elo, S., & Kyngäs, H. (2008). The qualitative content analysis process. Journal of Advanced Nursing, 62(1), 107-115. doi:10.1111/j.1365-2648.2007.04569.xRinner C Kohler M Hübner-Bloder G . Creating ISO/EN 13606 archetypes based on clinical information needs. In: Proceedings of EFMI Special Topic Conference, 14–15 April 2011, Lǎsko, Slovenia e-Health Across Borders Without Boundaries. 2011:14–15.Muñoz Carrero A Romero Gutiérrez A Marco Cuenca G . Manual práctico de interoperabilidad semántica para entornos sanitarios basada en arquetipos. Unidad de investigación en Telemedicina y e-Salud. Instituto de Salud Carlos III - Ministerio de Economía y Competitividad. 2013.Kalra D . Editorial principles for the development of standards for the structure and content of health records. 2012. https://www.rcplondon.ac.uk/sites/default/files/documents/editorial-principles-for-the-development-of-record-standards.pdf . Accessed July 18, 2015.Yuksel, M., & Dogac, A. (2011). Interoperability of Medical Device Information and the Clinical Applications: An HL7 RMIM based on the ISO/IEEE 11073 DIM. IEEE Transactions on Information Technology in Biomedicine, 15(4), 557-566. doi:10.1109/titb.2011.2151868Nagy M Hanzlicek P Precková P . Semantic interoperability in Czech healthcare environment supported by HL7 version 3. Methods Inf Med. 2010;49:186.LOPEZ, D., & BLOBEL, B. (2009). A development framework for semantically interoperable health information systems. International Journal of Medical Informatics, 78(2), 83-103. doi:10.1016/j.ijmedinf.2008.05.009Lopez DM Blobel B . Enhanced semantic interoperability by profiling health informatics standards. Methods Inf Med. 2009;48:170–177.Lopez DM Blobel B . Enhanced semantic interpretability by healthcare standards profiling. Stud Health Technol Inform. 2008;136:735.Knaup, P., Garde, S., & Haux, R. (2007). Systematic planning of patient records for cooperative care and multicenter research. International Journal of Medical Informatics, 76(2-3), 109-117. doi:10.1016/j.ijmedinf.2006.08.002Goossen, W. T. F., Ozbolt, J. G., Coenen, A., Park, H.-A., Mead, C., Ehnfors, M., & Marin, H. F. (2004). Development of a Provisional Domain Model for the Nursing Process for Use within the Health Level 7 Reference Information Model. Journal of the American Medical Informatics Association, 11(3), 186-194. doi:10.1197/jamia.m1085Anderson, H. V., Weintraub, W. S., Radford, M. J., Kremers, M. S., Roe, M. T., Shaw, R. E., … Tcheng, J. E. (2013). Standardized Cardiovascular Data for Clinical Research, Registries, and Patient Care. Journal of the American College of Cardiology, 61(18), 1835-1846. doi:10.1016/j.jacc.2012.12.047Jian, W.-S., Hsu, C.-Y., Hao, T.-H., Wen, H.-C., Hsu, M.-H., Lee, Y.-L., … Chang, P. (2007). Building a portable data and information interoperability infrastructure—framework for a standard Taiwan Electronic Medical Record Template. Computer Methods and Programs in Biomedicine, 88(2), 102-111. doi:10.1016/j.cmpb.2007.07.014Spigolon, D. N., & Moro, C. M. C. (2012). Arquétipos do conjunto de dados essenciais de enfermagem para atendimento de portadoras de endometriose. Revista Gaúcha de Enfermagem, 33(4), 22-32. doi:10.1590/s1983-14472012000400003Späth, M. B., & Grimson, J. (2011). Applying the archetype approach to the database of a biobank information management system. International Journal of Medical Informatics, 80(3), 205-226. doi:10.1016/j.ijmedinf.2010.11.002Smith, K., & Kalra, D. (2008). Electronic health records in complementary and alternative medicine. International Journal of Medical Informatics, 77(9), 576-588. doi:10.1016/j.ijmedinf.2007.11.005Bax, M. P., Kalra, D., & Santos, M. R. (2012). Dealing with the Archetypes Development Process for a Regional EHR System. Applied Clinical Informatics, 03(03), 258-275. doi:10.4338/aci-2011-12-ra-0074Moner D Moreno A Maldonado JA . Using archetypes for defining CDA templates. Stud Health Technol Inform. 2012;180:53–57.Moner D Maldonado JA Boscá D . CEN EN13606 normalisation framework implementation experiences. In: Seamless Care, Safe Care: The Challenges of Interoperability and Patient Safety in Health Care: Proceedings of the EFMI Special Topic Conference, June 2–4, 2010; Reykjavik, Iceland. IOS Press; 2010: 136.Marcos, M., Maldonado, J. A., Martínez-Salvador, B., Boscá, D., & Robles, M. (2013). Interoperability of clinical decision-support systems and electronic health records using archetypes: A case study in clinical trial eligibility. Journal of Biomedical Informatics, 46(4), 676-689. doi:10.1016/j.jbi.2013.05.004Leslie H . International developments in openEHR archetypes and templates. Health Inf Manag J. 2008;37:38.Kohl CD Garde S Knaup P . Facilitating secondary use of medical data by using openEHR archetypes. Stud Health Technol Inform. 2009;160:1117–1121.Garde, S., Hovenga, E., Buck, J., & Knaup, P. (2007). Expressing clinical data sets with openEHR archetypes: A solid basis for ubiquitous computing. International Journal of Medical Informatics, 76, S334-S341. doi:10.1016/j.ijmedinf.2007.02.004Garcia D Moro CM Cicogna PE . Method to integrate clinical guidelines into the electronic health record (EHR) by applying the archetypes approach. Stud Health Technol Inform. 2012;192:871–875.Duftschmid, G., Rinner, C., Kohler, M., Huebner-Bloder, G., Saboor, S., & Ammenwerth, E. (2013). The EHR-ARCHE project: Satisfying clinical information needs in a Shared Electronic Health Record System based on IHE XDS and Archetypes. International Journal of Medical Informatics, 82(12), 1195-1207. doi:10.1016/j.ijmedinf.2013.08.002Dias, R. D., Cook, T. W., & Freire, S. M. (2011). Modeling healthcare authorization and claim submissions using the openEHR dual-model approach. BMC Medical Informatics and Decision Making, 11(1). doi:10.1186/1472-6947-11-60Buck, J., Garde, S., Kohl, C. D., & Knaup-Gregori, P. (2009). Towards a comprehensive electronic patient record to support an innovative individual care concept for premature infants using the openEHR approach. International Journal of Medical Informatics, 78(8), 521-531. doi:10.1016/j.ijmedinf.2009.03.001Puentes, J., Roux, M., Montagner, J., & Lecornu, L. (2012). Development framework for a patient-centered record. Computer Methods and Programs in Biomedicine, 108(3), 1036-1051. doi:10.1016/j.cmpb.2012.06.007Liu, D., Wang, X., Pan, F., Yang, P., Xu, Y., Tang, X., … Rao, K. (2010). Harmonization of health data at national level: A pilot study in China. International Journal of Medical Informatics, 79(6), 450-458. doi:10.1016/j.ijmedinf.2010.03.002Liu, D., Wang, X., Pan, F., Xu, Y., Yang, P., & Rao, K. (2008). Web-based infectious disease reporting using XML forms. International Journal of Medical Informatics, 77(9), 630-640. doi:10.1016/j.ijmedinf.2007.10.011Kim, Y., & Park, H.-A. (2011). Development and Validation of Detailed Clinical Models for Nursing Problems in Perinatal care. Applied Clinical Informatics, 02(02), 225-239. doi:10.4338/aci-2011-01-ra-0007Khan, W. A., Hussain, M., Afzal, M., Amin, M. B., Saleem, M. A., & Lee, S. (2013). Personalized-Detailed Clinical Model for Data Interoperability Among Clinical Standards. Telemedicine and e-Health, 19(8), 632-642. doi:10.1089/tmj.2012.0189Jing, X., Kay, S., Marley, T., Hardiker, N. R., & Cimino, J. J. (2012). Incorporating personalized gene sequence variants, molecular genetics knowledge, and health knowledge into an EHR prototype based on the Continuity of Care Record standard. Journal of Biomedical Informatics, 45(1), 82-92. doi:10.1016/j.jbi.2011.09.001Hsu, W., Taira, R. K., El-Saden, S., Kangarloo, H., & Bui, A. A. T. (2012). Context-Based Electronic Health Record: Toward Patient Specific Healthcare. IEEE Transactions on Information Technology in Biomedicine, 16(2), 228-234. doi:10.1109/titb.2012.2186149Hoy D Hardiker NR McNicoll IT . Collaborative development of clinical templates as a national resource. Int J Med Inf. 2009;78:S3–S8.Buyl, R., & Nyssen, M. (2009). Structured electronic physiotherapy records. International Journal of Medical Informatics, 78(7), 473-481. doi:10.1016/j.ijmedinf.2009.02.007D’Amore JD Mandel JC Kreda DA . Are Meaningful Use Stage 2 certified EHRs ready for interoperability? Findings from the SMART C-CDA Collaborative. J Am Med Inform Assoc. 2014. Advance access published; doi:10.1136/amiajnl-2014-002883.Kalra D Tapuria A Austin T . Quality requirements for EHR archetypes. In: MIE; 2012: 48–52.Garde S Hovenga EJ Gränz J . Managing archetypes for sustainable and semantically interoperable electronic health records. Electron J Health Inform. 2007;2:e9.Madsen M Leslie H Hovenga EJS . Sustainable clinical knowledge management: an archetype development life cycle. Stud Health Technol Inform. 2010;151:115–132.Kohl CD Garde S Knaup P . Facilitating the openEHR approach-organizational structures for defining high-quality archetypes. Stud Health Technol Inform. 2008;136:437.Stroetmann VN Kalra D Lewalle P . Semantic interoperability for better health and safer healthcare. European Commission, Directorate-General Information Society and Media; 2009. http://dx.doi.org/10.2759/38514

Tisotumab Vedotin in Combination with Carboplatin, Pembrolizumab, or Bevacizumab in Recurrent or Metastatic Cervical Cancer:Results from the innovaTV 205/GOG-3024/ENGOT-cx8 Study

PURPOSE Tissue factor is highly expressed in cervical carcinoma and can be targeted by tisotumab vedotin (TV), an antibody-drug conjugate. This phase Ib/II study evaluated TV in combination with bevacizumab, pembrolizumab, or carboplatin for recurrent or metastatic cervical cancer (r/mCC). METHODS This open-label, multicenter study (ClinicalTrials.gov identifier: NCT03786081) included dose-escalation arms that assessed dose-limiting toxicities (DLTs) and identified the recommended phase II dose (RP2D) of TV in combination with bevacizumab (arm A), pembrolizumab (arm B), or carboplatin (arm C). The dose-expansion arms evaluated TV antitumor activity and safety at RP2D in combination with carboplatin as first-line (1L) treatment (arm D) or with pembrolizumab as 1L (arm E) or second-/third-line (2L/3L) treatment (arm F). The primary end point of dose expansion was objective response rate (ORR). RESULTS A total of 142 patients were enrolled. In dose escalation (n = 41), no DLTs were observed; the RP2D was TV 2 mg/kg plus bevacizumab 15 mg/kg on day 1 once every 3 weeks, pembrolizumab 200 mg on day 1 once every 3 weeks, or carboplatin AUC 5 on day 1 once every 3 weeks. In dose expansion (n = 101), the ORR was 54.5% (n/N, 18/33; 95% CI, 36.4 to 71.9) with 1L TV + carboplatin (arm D), 40.6% (n/N, 13/32; 95% CI, 23.7 to 59.4) with 1L TV + pembrolizumab (arm E), and 35.3% (12/34; 19.7 to 53.5) with 2L/3L TV + pembrolizumab (arm F). The median duration of response was 8.6 months, not reached, and 14.1 months, in arms D, E, and F, respectively. Grade ≥3 adverse events (≥15%) were anemia, diarrhea, nausea, and thrombocytopenia in arm D and anemia in arm F (none ≥15%, arm E).CONCLUSION TV in combination with bevacizumab, carboplatin, or pembrolizumab demonstrated manageable safety and encouraging antitumor activity in treatment-naive and previously treated r/mCC.</p

Using quantile regression to investigate racial disparities in medication non-adherence

<p>Abstract</p> <p>Background</p> <p>Many studies have investigated racial/ethnic disparities in medication non-adherence in patients with type 2 diabetes using common measures such as medication possession ratio (MPR) or gaps between refills. All these measures including MPR are quasi-continuous and bounded and their distribution is usually skewed. Analysis of such measures using traditional regression methods that model mean changes in the dependent variable may fail to provide a full picture about differential patterns in non-adherence between groups.</p> <p>Methods</p> <p>A retrospective cohort of 11,272 veterans with type 2 diabetes was assembled from Veterans Administration datasets from April 1996 to May 2006. The main outcome measure was MPR with quantile cutoffs Q1-Q4 taking values of 0.4, 0.6, 0.8 and 0.9. Quantile-regression (QReg) was used to model the association between MPR and race/ethnicity after adjusting for covariates. Comparison was made with commonly used ordinary-least-squares (OLS) and generalized linear mixed models (GLMM).</p> <p>Results</p> <p>Quantile-regression showed that Non-Hispanic-Black (NHB) had statistically significantly lower MPR compared to Non-Hispanic-White (NHW) holding all other variables constant across all quantiles with estimates and p-values given as -3.4% (p = 0.11), -5.4% (p = 0.01), -3.1% (p = 0.001), and -2.00% (p = 0.001) for Q1 to Q4, respectively. Other racial/ethnic groups had lower adherence than NHW only in the lowest quantile (Q1) of about -6.3% (p = 0.003). In contrast, OLS and GLMM only showed differences in mean MPR between NHB and NHW while the mean MPR difference between other racial groups and NHW was not significant.</p> <p>Conclusion</p> <p>Quantile regression is recommended for analysis of data that are heterogeneous such that the tails and the central location of the conditional distributions vary differently with the covariates. QReg provides a comprehensive view of the relationships between independent and dependent variables (i.e. not just centrally but also in the tails of the conditional distribution of the dependent variable). Indeed, without performing QReg at different quantiles, an investigator would have no way of assessing whether a difference in these relationships might exist.</p